according to the odds, you've got a 33% chance of either paring the board or getting quads to beat a straight or flush.
That's actually not bad. Set vs draw is 75% favorite.
So, if you figure half the time he's in a position where you're a big favorite (on the draw, lower set, 2 pair, tptk) which seems reasonable, then you're better off calling. 6 handed, your odds only improve.
The only other hand that could have you is AA but why would he just call the $45 preflop with that.
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